The APOE ε4 Allele Affects Cognitive Functions Differently in Carriers of APP Mutations Compared to Carriers of PSEN1 Mutations in Autosomal-Dominant Alzheimer's Disease.

ABSTRACT: Mounting evidence shows that the APOE ε4 allele interferes with cognition in sporadic Alzheimer's disease. Less is known about APOE in autosomal-dominant Alzheimer's disease (adAD). The present study explored the effects on cognition associated with the gene-gene interactions between the APOE gene and the APP and PSEN1 genes in adAD. This study includes mutation carriers (MC) and non-carriers (NC) from adAD families with mutations in APP (n = 28 and n = 25; MC and NC, respectively) and PSEN1 (n = 12 and n = 15; MC and NC, respectively) that represent the complete spectrum of disease: AD dementia (n = 8) and mild cognitive impairment (MCI, n = 15 and presymptomatic AD, n = 17). NC represented unimpaired normal aging. There was no significant difference in the distribution of APOE ε4 (absenc

SUBMITTER: Almkvist O 

PROVIDER: S-EPMC8701239 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature