Ontology highlight
ABSTRACT:
SUBMITTER: Leu JG
PROVIDER: S-EPMC8703696 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Leu Jyh-Gang JG Wang Chien-Mei CM Chen Chao-Yi CY Yang Yi-Feng YF Shih Chin-Yu CY Lin Jiun-Tsai JT Chen Han-Min HM Liang Yao-Jen YJ
Life (Basel, Switzerland) 20211216 12
Ischemia followed by blood supply reperfusion in cardiomyocytes leads to an overproduction of free radicals and a rapid decrease of adenosine triphosphate concentration. The cardioprotective effect of a potential drug, adenine, was evaluated using H9c2 rat cardiomyoblasts. After hypoxia-reoxygenation (HR) treatment consisting of hypoxia for 21 h followed by reoxygenation for 6 h, it was revealed that pretreatment with 200 µM adenine for 2 h effectively prevented HR-induced cell death. Adenine al ...[more]