Ontology highlight
ABSTRACT:
SUBMITTER: Kalafatis D
PROVIDER: S-EPMC8704101 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Kalafatis Dimitrios D Löfdahl Anna A Näsman Per P Dellgren Göran G Wheelock Åsa M ÅM Elowsson Rendin Linda L Sköld Magnus M Westergren-Thorsson Gunilla G
International journal of molecular sciences 20211214 24
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with an unmet need of biomarkers that can aid in the diagnostic and prognostic assessment of the disease and response to treatment. In this two-part explorative proteomic study, we demonstrate how proteins associated with tissue remodeling, inflammation and chemotaxis such as MMP7, CXCL13 and CCL19 are released in response to aberrant extracellular matrix (ECM) in IPF lung. We used a novel ex vivo model where decellulariz ...[more]