Unknown

Dataset Information

0

Deep Learning for Rapid Identification of Microbes Using Metabolomics Profiles.


ABSTRACT: Rapid detection of viable microbes remains a challenge in fields such as microbial food safety. We here present the application of deep learning algorithms to the rapid detection of pathogenic and non-pathogenic microbes using metabolomics data. Microbes were incubated for 4 h in a protein-free defined medium, followed by 1D 1H nuclear magnetic resonance (NMR) spectroscopy measurements. NMR spectra were analyzed by spectral binning in an untargeted metabolomics approach. We trained multilayer ("deep") artificial neural networks (ANN) on the data and used the resulting models to predict spectra of unknown microbes. ANN predicted unknown microbes in this laboratory setting with an average accuracy of 99.2% when using a simple feature selection method. We also describe learning behavior of the employed ANN and the optimization strategies that worked well with these networks for our datasets. Performance was compared to other current data analysis methods, and ANN consistently scored higher than random forest models and support vector machines, highlighting the potential of deep learning in metabolomics data analysis.

SUBMITTER: Wang D 

PROVIDER: S-EPMC8704490 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC6960993 | biostudies-literature
| S-EPMC7575644 | biostudies-literature
| S-EPMC9177968 | biostudies-literature
| S-EPMC7505912 | biostudies-literature
| S-EPMC7901771 | biostudies-literature
| S-EPMC7591901 | biostudies-literature
| S-EPMC6443501 | biostudies-literature
| S-EPMC8359798 | biostudies-literature
| S-EPMC4303330 | biostudies-other
2019-11-13 | GSE140262 | GEO