Ontology highlight
ABSTRACT:
SUBMITTER: Acar IE
PROVIDER: S-EPMC8705464 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Acar I Erkin IE Willems Esther E Kersten Eveline E Keizer-Garritsen Jenneke J Kragt Else E Bakker Bjorn B Galesloot Tessel E TE Hoyng Carel B CB Fauser Sascha S van Gool Alain J AJ Lechanteur Yara T E YTE Koertvely Elod E Nogoceke Everson E Gloerich Jolein J de Jonge Marien I MI Lorés-Motta Laura L den Hollander Anneke I AI
Journal of personalized medicine 20211125 12
Age-related macular degeneration (AMD) is a major cause of vision loss among the elderly in the Western world. The complement system has been identified as one of the main AMD disease pathways. We performed a comprehensive expression analysis of 32 complement proteins in plasma samples of 255 AMD patients and 221 control individuals using mass spectrometry-based semi-quantitative multiplex profiling. We detected significant associations of complement protein levels with age, sex and body-mass in ...[more]