Ontology highlight
ABSTRACT:
SUBMITTER: Tarasova E
PROVIDER: S-EPMC8705882 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Tarasova Elvira E Okimoto Noriaki N Feng Shanshan S Nerukh Dmitry D Khayat Reza R Taiji Makoto M
Physical chemistry chemical physics : PCCP 20211110 43
Spatiotemporal regulation of viral capsid assembly ensures the selection of the viral genome for encapsidation. The porcine circovirus 2 is the smallest autonomously replicating pathogenic virus, yet how PCV2 capsid assembly is regulated to occur within the nucleus remains unknown. We report that pure PCV2 capsid proteins, in the absence of nucleic acids, require acidic conditions to assemble into empty capsids <i>in vitro</i>. By employing constant pH replica exchange molecular dynamics, we unv ...[more]