Optimal Heart Rate and Prognosis in Patients with Cardiac Amyloidosis.
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ABSTRACT: Background
Optimal heart rate (HR) that associates with higher cardiac output and greater clinical outcomes in patients with cardiac amyloidosis remains unknown.Methods
Consecutive patients with sinus rhythm who were diagnosed with cardiac amyloidosis at our institute between February 2015 and February 2021 were retrospectively included. Ideal HR, at which E-wave and A-wave stand adjacent without any overlaps in the trans-mitral flow echocardiography, was calculated by the formula: 86.8-0.08 × deceleration time (msec). The association between optimal HR and cardiac death or heart failure readmission was investigated.Results
Ten patients (median 74 years old, 8 men) were included. On median, actual HR was 64 bpm and ideal HR was 69 bpm. An incidence rate of the primary endpoint in the sub-optimal HR group tended to be higher than optimal HR group: one of the four patients in optimal HR group had events (25%); two of the two patients in higher HR group had events (100%); two of the four patients in lower HR group had events (50%).Conclusions
The optimal HR was associated with greater clinical outcomes in patients with cardiac amyloidosis. The clinical impact of aggressive HR optimization in this cohort remains the next concern.
SUBMITTER: Izumida T
PROVIDER: S-EPMC8706408 | biostudies-literature |
REPOSITORIES: biostudies-literature
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