Ontology highlight
ABSTRACT:
SUBMITTER: Su WQ
PROVIDER: S-EPMC8706696 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Su Wen-Qing WQ Yu Xue-Jie XJ Zhou Chuan-Min CM
Viruses 20211209 12
In the past year and a half, SARS-CoV-2 has caused 240 million confirmed cases and 5 million deaths worldwide. Autophagy is a conserved process that either promotes or inhibits viral infections. Although coronaviruses are known to utilize the transport of autophagy-dependent vesicles for the viral life cycle, the underlying autophagy-inducing mechanisms remain largely unexplored. Using several autophagy-deficient cell lines and autophagy inhibitors, we demonstrated that SARS-CoV-2 ORF3a was able ...[more]