Ontology highlight
ABSTRACT:
SUBMITTER: Gruscheski L
PROVIDER: S-EPMC8706714 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Gruscheski Lena L Brand Thomas T
Journal of cardiovascular development and disease 20211123 12
The Popeye domain-containing (POPDC) gene family, consisting of <i>Popdc1</i> (also known as <i>Bves</i>)<i>, Popdc2</i>, and <i>Popdc3</i>, encodes transmembrane proteins abundantly expressed in striated muscle. POPDC proteins have recently been identified as cAMP effector proteins and have been proposed to be part of the protein network involved in cAMP signaling. However, their exact biochemical activity is presently poorly understood. Loss-of-function mutations in animal models causes abnorm ...[more]