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Role of Circulating Biomarkers in Platinum-Resistant Ovarian Cancer.


ABSTRACT: Ovarian cancer (OC) is the second most common cause of death in women with gynecological cancer. Considering the poor prognosis, particularly in the case of platinum-resistant (PtR) disease, a huge effort was made to define new biomarkers able to help physicians in approaching and treating these challenging patients. Currently, most data can be obtained from tumor biopsy samples, but this is not always available and implies a surgical procedure. On the other hand, circulating biomarkers are detected with non-invasive methods, although this might require expensive techniques. Given the fervent hope in their value, here we focused on the most studied circulating biomarkers that could play a role in PtR OC.

SUBMITTER: Sassu CM 

PROVIDER: S-EPMC8707281 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Role of Circulating Biomarkers in Platinum-Resistant Ovarian Cancer.

Sassu Carolina Maria CM   Palaia Innocenza I   Boccia Serena Maria SM   Caruso Giuseppe G   Perniola Giorgia G   Tomao Federica F   Di Donato Violante V   Musella Angela A   Muzii Ludovico L  

International journal of molecular sciences 20211220 24


Ovarian cancer (OC) is the second most common cause of death in women with gynecological cancer. Considering the poor prognosis, particularly in the case of platinum-resistant (PtR) disease, a huge effort was made to define new biomarkers able to help physicians in approaching and treating these challenging patients. Currently, most data can be obtained from tumor biopsy samples, but this is not always available and implies a surgical procedure. On the other hand, circulating biomarkers are dete  ...[more]

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