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Effects of Platycodon grandiflorum on Gut Microbiome and Immune System of Immunosuppressed Mouse.


ABSTRACT: Platycodon grandiflorum (PG) is a perennial plant that has been used as a traditional remedy to control immune-related diseases. PG was steamed and dried to improve its taste (PGS). The aim of the study was to investigate the effects of PG and PGS (PG-diets) on the gut microbiome and immune system. We treated PG-diets to immunosuppressed mice via cyclophosphamide (CPA) injection. After two weeks of the supplement, we evaluated specific genera related to body weight and serum immunoglobulin levels and analyzed 16S rRNA sequencing and metagenomics statistical analysis. PG-diets groups showed an increased abundance of microorganisms in immunodeficient mice compared to the control group (NC). Moreover, Akkermansia significantly decreased in response to the CPA in the NC group at the genus level, whereas its abundance increased in the PG-diets groups. We also found that the modulation of the gut microbiome by PG-diets was correlated with body weight, IgA, and IgM levels. The results demonstrate that PG-diets may improve the health benefits of immunosuppressed mice by altering the gut microbiome, though not much difference was found between PG and PGS treatments. Finally, this is the first study showing the effects of PGS-diets on the gut microbiome and immune system as a potential nourishing immunity supplement.

SUBMITTER: Jhang SY 

PROVIDER: S-EPMC8707369 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Effects of <i>Platycodon grandiflorum</i> on Gut Microbiome and Immune System of Immunosuppressed Mouse.

Jhang So-Yun SY   Lee Sung-Hyen SH   Lee Eun-Byeol EB   Choi Ji-Hye JH   Bang Sohyun S   Jeong Misun M   Jang Hwan-Hee HH   Kim Hyun-Ju HJ   Lee Hae-Jeung HJ   Jeong Hyun-Cheol HC   Lee Sung-Jin SJ  

Metabolites 20211129 12


<i>Platycodon grandiflorum</i> (PG) is a perennial plant that has been used as a traditional remedy to control immune-related diseases. PG was steamed and dried to improve its taste (PGS). The aim of the study was to investigate the effects of PG and PGS (PG-diets) on the gut microbiome and immune system. We treated PG-diets to immunosuppressed mice via cyclophosphamide (CPA) injection. After two weeks of the supplement, we evaluated specific genera related to body weight and serum immunoglobuli  ...[more]

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