Ontology highlight
ABSTRACT:
SUBMITTER: Butnariu LI
PROVIDER: S-EPMC8707808 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Butnariu Lăcrămioara Ionela LI Țarcă Elena E Cojocaru Elena E Rusu Cristina C Moisă Ștefana Maria ȘM Leon Constantin Maria-Magdalena MM Gorduza Eusebiu Vlad EV Trandafir Laura Mihaela LM
Journal of clinical medicine 20211213 24
Cystic fibrosis (CF) is a monogenic autosomal recessive disease caused by cystic fibrosis transmembrane conductance regulator (<i>CFTR</i>) gene mutations. CF is characterized by a high phenotypic variability present even in patients with the same genotype. This is due to the intervention of modifier genes that interact with both the CFTR gene and environmental factors. The purpose of this review is to highlight the role of non-CFTR genetic factors (modifier genes) that contribute to phenotypic ...[more]