Ontology highlight
ABSTRACT:
SUBMITTER: Pavlopoulou A
PROVIDER: S-EPMC8708251 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Pavlopoulou Athanasia A Asfa Seyedehsadaf S Gioukakis Evangelos E Mavragani Ifigeneia V IV Nikitaki Zacharenia Z Takan Işıl I Pouget Jean-Pierre JP Harrison Lynn L Georgakilas Alexandros G AG
Molecules (Basel, Switzerland) 20211215 24
Different types of DNA lesions forming in close vicinity, create clusters of damaged sites termed as "clustered/complex DNA damage" and they are considered to be a major challenge for DNA repair mechanisms resulting in significant repair delays and induction of genomic instability. Upon detection of DNA damage, the corresponding DNA damage response and repair (DDR/R) mechanisms are activated. The inability of cells to process clustered DNA lesions efficiently has a great impact on the normal fun ...[more]