Ontology highlight
ABSTRACT:
SUBMITTER: Tverskoi AM
PROVIDER: S-EPMC8708600 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Tverskoi Artem M AM Poluektov Yuri M YM Klimanova Elizaveta A EA Mitkevich Vladimir A VA Makarov Alexander A AA Orlov Sergei N SN Petrushanko Irina Yu IY Lopina Olga D OD
International journal of molecular sciences 20211209 24
Cardiotonic steroids (CTSs) are specific inhibitors of Na,K-ATPase (NKA). They induce diverse physiological effects and were investigated as potential drugs in heart diseases, hypertension, neuroinflammation, antiviral and cancer therapy. Here, we compared the inhibition mode and binding of CTSs, such as ouabain, digoxin and marinobufagenin to NKA from pig and rat kidneys, containing CTSs-<b>s</b>ensitive (α1<b>S</b>) and -<b>r</b>esistant (α1<b>R</b>) α1-subunit, respectively. Marinobufagenin i ...[more]