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Potentially Toxic Element Levels in Atmospheric Particulates and Health Risk Estimation around Industrial Areas of Maros, Indonesia.

ABSTRACT: Air quality deterioration is a major environmental problem in Indonesia. This study evaluated the levels and health risks of potentially toxic elements (PTEs) in Maros Regency, Indonesia. Total suspended particulate matter was collected from industrial areas for PTE (Al, Pb, Cr, Cu, Ni, As and Zn) analysis using inductively coupled plasma optical emission spectrometry (ICP-OES). Samples were collected from six critical areas in the Bantimurung region as that is where marble, cement and limestone industries are located. A calculation of the non-carcinogenic and cancer risks was performed to determine the potential health exposures in adults and children. A Monte Carlo simulation with 10,000 iterations and a sensitivity analysis was carried out to identify the risk probability and the most sensitive variable contributing to cancer risk from PTE exposure in humans. The results showed that the concentration of PTEs decreased in the order of Zn > Al > Cr > Pb > Cu > Ni > As in the wet season, and Zn > Al > Pb > As > Cr > Cu > Ni in the dry season. The hazard index (HI) value for children was 2.12, indicating a high non-carcinogenic risk for children. The total cancer risk (TCR) values in adults and children were 3.11 × 10^-5 and 1.32 × 10^-4, respectively, implying that both are at risk for developing cancer. The variables with the most contribution to cancer risk from As, Cr and Pb exposure in adults and children were As concentration (33.9% and 41.0%); exposure duration (ED) (34.3%) and SA (40.7%); and SA (98.7 % and 45.4%), respectively. These findings could be used as the scientific basis for public health intervention and to raise awareness of the harmful health effects of particulate bound PTEs.

SUBMITTER: Rauf AU

PROVIDER: S-EPMC8708896 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:Agricultural lands, especially those where wheat is cultivated, in the vicinity of intense anthropogenic activities may be laden with potentially toxic elements (PTEs), resulting in increased risk for human health. In this study we monitored three regions located in central Greece, currently cultivated with wheat: Domokos and Eretria, two areas with abandoned chromium mines, but never studied before, and the industrial area of Volos, near a major steel factory. All soils were alkaline with medium CaCO3 content. As expected, Cr was extremely high in the first two areas (705.2 in Eretria and 777.5 mg kg-1 in Domokos); Ni was also found elevated (1227 in Eretria, 1315 in Domokos and 257.6 mg kg-1 in the steel factory), while other harmful metals (Cd, Cu, Pb and Zn) were rather low. As a result, pollution load index, a cumulative index showing the contamination level of an area, was higher than 1.0 in all three areas (Eretria = 2.20, Domokos = 2.28, and steel factory = 1.61), indicating high contamination and anthropogenic inputs. As for the wheat parts (shoots and grains), they were found to have no elevated concentrations of any of the measured metals in all three study areas, probably due to the alkaline soil pH that decelerates metal mobility. This was also confirmed by the very low soil-to-plant transfer coefficient values for all metals. In assessing the possible risk concerning human health, we found that the soil-to-human pathway would induce no significant risk (exhibited by hazard index of less than 1.0), while the risk from grain-to-human resulted in considerable risk for human health in the steel factory of Volos (where HI > 1.0). Our findings suggest that rural areas never studied before with a history in some offensive anthropogenic activity can prove to be a contamination hotspot; we regard this study as a pivotal for similarly never-visited-before areas casually cultivated with wheat (or other important crops for human nutrition). We further recognize the need for a more in-depth study that would acknowledge the geochemical speciation of the studied metals and also monitor other important crops and their possible uptake of PTEs.

Project description:BackgroundThis study aims to investigate the effects of water soluble particulate matter (WSPM) on the viability and protein expression profile of human lung adenocarcinoma cell A549 in the Bayou Obo rare earth mining area, and explore the influence of WSPM on the A549 cell cycle.ResultsIt was found that WSPM can inhibit the viability of A549 cells and induce cell arrest in the G2/M phase. Compared with controls, exposure to WSPM10 and WSPM2.5 induced 134 and 116 proteins to be differentially expressed in A549 cells, respectively. In addition, 33 and 31 differentially expressed proteins were further confirmed, and was consistent with the proteomic analysis. The most prominent enrichment in ribosome-associated proteins were presented. When RPL6, RPL13, or RPL18A gene expression was inhibited, A549 cells were arrested in the G1 phase, affecting the expression of Cyclin D1, p21, RB1, Cyclin A2, Cyclin B1, CDC25A, CDK2, CHEK2 and E2F1. Furthermore, the La3+, Ce3+, Nd3+ and F- in WSPM also inhibited the viability of A549 cells. After 24 h of exposure to 2 mM of NaF, A549 cells were also arrested in the G2/M phase, while the other three compounds did not have this effect. These four compounds affected the cell cycle regulatory factors in A549 cells, mainly focusing on effecting the expression of CDK2, CDK4, RB1, ATM, TP53 and MDM2 genes. These results are consistent with the those from WSPM exposure.ConclusionsThese results revealed that WSPM from rare earth mines decreased the viability of A549 cells, and induced cell cycle G2/M phase arrest, and even apoptosis, which may be independent of the NF-κB/MYD88 pathway, and be perceived by the TLR4 receptor. The dysfunction of the cell cycle is correlated to the down-expression of ribosomal proteins (RPs). However, it is not the direct reason for the A549 cell arrest in the G2/M phase. La3+, Ce3+, and F- are probably the main toxic substances in WSPM, and may be regulate the A549 cell cycle by affecting the expression of genes, such as MDM2, RB1, ATM, TP53, E2F1, CDK2 and CDK4. These results indicate the importance for further research into the relationship between APM and lung cancer.

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Potentially Toxic Element Levels in Atmospheric Particulates and Health Risk Estimation around Industrial Areas of Maros, Indonesia.

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