Ontology highlight
ABSTRACT:
SUBMITTER: Kanoh H
PROVIDER: S-EPMC8710550 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Kanoh Hirotaka H Iwashita Shinzo S Kuraishi Takayuki T Goto Akira A Fuse Naoyuki N Ueno Haruna H Nimura Mariko M Oyama Tomohito T Tang Chang C Watanabe Ryo R Hori Aki A Momiuchi Yoshiki Y Ishikawa Hiroki H Suzuki Hiroaki H Nabe Kumiko K Takagaki Takeshi T Fukuzaki Masataka M Tong Li-Li LL Yamada Sinya S Oshima Yoshiteru Y Aigaki Toshiro T Dow Julian A T JAT Davies Shireen-Anne SA Kurata Shoichiro S
iScience 20211118 12
The nuclear factor-kappa B (NF-κB) pathway is an evolutionarily conserved signaling pathway that plays a central role in immune responses and inflammation. Here, we show that <i>Drosophila</i> NF-κB signaling is activated via a pathway in parallel with the Toll receptor by receptor-type guanylate cyclase, Gyc76C. Gyc76C produces cyclic guanosine monophosphate (cGMP) and modulates NF-κB signaling through the downstream Tollreceptor components dMyd88, Pelle, Tube, and Dif/Dorsal (NF-κB). The cGMP ...[more]