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Sirtuin 5 is Dispensable for CD8⁺ T Cell Effector and Memory Differentiation.

ABSTRACT: CD8⁺ T cell effector and memory differentiation is tightly controlled at multiple levels including transcriptional, metabolic, and epigenetic regulation. Sirtuin 5 (SIRT5) is a protein deacetylase mainly located at mitochondria, but it remains unclear whether SIRT5 plays key roles in regulating CD8⁺ T cell effector or memory formation. Herein, with adoptive transfer of Sirt5^+/+ or Sirt5^-/- OT-1 cells and acute Listeria monocytogenes infection model, we demonstrate that SIRT5 deficiency does not affect CD8⁺ T cell effector function and that SIRT5 is not required for CD8⁺ T cell memory formation. Moreover, the recall response of SIRT5 deficient memory CD8⁺ T cells is comparable with Sirt5^+/+ memory CD8⁺ T cells. Together, these observations suggest that SIRT5 is dispensable for the effector function and memory differentiation of CD8⁺ T cells.

SUBMITTER: Duan Q

PROVIDER: S-EPMC8710726 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Sirtuin 5 is Dispensable for CD8+ T Cell Effector and Memory Differentiation.

Duan Qianqian Q Ding Jiying J Li Fangfang F Liu Xiaowei X Zhao Yunan Y Yu Hongxiu H Liu Yong Y Zhang Lianjun L

Frontiers in cell and developmental biology 20211213

CD8+ T cell effector and memory differentiation is tightly controlled at multiple levels including transcriptional, metabolic, and epigenetic regulation. Sirtuin 5 (SIRT5) is a protein deacetylase mainly located at mitochondria, but it remains unclear whether SIRT5 plays key roles in regulating CD8+ T cell effector or memory formation. Herein, with adoptive transfer of Sirt5+/+ or Sirt5-/- OT-1 cells and acute Listeria monocytogenes infection mo ...[more]

PMID: 34966740

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