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ZFTA-YAP1 fusion-positive ependymoma can occur in the spinal cord: Letter to the editor.

ABSTRACT: We report a case of spinal ependymoma with ZFTA-YAP1 fusion, occurring in a 5-year-old boy who complained of back pain. It was high-grade ependymoma, developed in the spinal cord at the level of T9-12. Since ZFTA-YAP1 fusion-positive ependymoma has never been reported in the spinal cord, this case is exceptional and worth reporting because the anatomical location, genetics, and epigenetics are important parameters in the classification of the ependymal tumor. This is the first case of spinal ependymoma harboring ZFTA-fusion to be diagnosed by NGS and Sanger studies to the best of our knowledge.

SUBMITTER: Lim KY

PROVIDER: S-EPMC8713521 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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ZFTA-YAP1 fusion-positive ependymoma can occur in the spinal cord: Letter to the editor.

Lim Ka Young KY Lee Kwang Hoon KH Phi Ji Hoon JH Yun Hongseok H Won Jae Kyung JK Choi Seung Hong SH Park Sung-Hye SH

Brain pathology (Zurich, Switzerland) 20210910 1

We report a case of spinal ependymoma with ZFTA-YAP1 fusion, occurring in a 5-year-old boy who complained of back pain. It was high-grade ependymoma, developed in the spinal cord at the level of T9-12. Since ZFTA-YAP1 fusion-positive ependymoma has never been reported in the spinal cord, this case is exceptional and worth reporting because the anatomical location, genetics, and epigenetics are important parameters in the classification of the ependymal tumor. This is the first case of spinal epe ...[more]

PMID: 34506076

Dataset Information

ZFTA-YAP1 fusion-positive ependymoma can occur in the spinal cord: Letter to the editor.

Publications

ZFTA-YAP1 fusion-positive ependymoma can occur in the spinal cord: Letter to the editor.

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