DNA polymerase mu: An inflexible scaffold for substrate flexibility.
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ABSTRACT:
SUBMITTER: Kaminski AM
PROVIDER: S-EPMC8713560 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
DNA polymerase mu: An inflexible scaffold for substrate flexibility.
Kaminski Andrea M AM Bebenek Katarzyna K Pedersen Lars C LC Kunkel Thomas A TA
DNA repair 20200901
DNA polymerase μ is a Family X member that participates in repair of DNA double strand breaks (DSBs) by non-homologous end joining. Its role is to fill short gaps arising as intermediates in the process of V(D)J recombination and during processing of accidental double strand breaks. Pol μ is the only known template-dependent polymerase that can repair non-complementary DSBs with unpaired 3´primer termini. Here we review the unique properties of Pol μ that allow it to productively engage such a h ...[more]
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