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Serotype Replacement after Introduction of 10-Valent and 13-Valent Pneumococcal Conjugate Vaccines in 10 Countries, Europe.


ABSTRACT: We evaluated invasive pneumococcal disease (IPD) during 8 years of infant pneumococcal conjugate vaccine (PCV) programs using 10-valent (PCV10) and 13-valent (PCV13) vaccines in 10 countries in Europe. IPD incidence declined during 2011-2014 but increased during 2015-2018 in all age groups. From the 7-valent PCV period to 2018, IPD incidence declined by 42% in children <5 years of age, 32% in persons 5-64 years of age, and 7% in persons >65 years of age; non-PCV13 serotype incidence increased by 111%, 63%, and 84%, respectively, for these groups. Trends were similar in countries using PCV13 or PCV10, despite different serotype distribution. In 2018, serotypes in the 15-valent and 20-valent PCVs represented one third of cases in children <5 years of age and two thirds of cases in persons >65 years of age. Non-PCV13 serotype increases reduced the overall effect of childhood PCV10/PCV13 programs on IPD. New vaccines providing broader serotype protection are needed.

SUBMITTER: Hanquet G 

PROVIDER: S-EPMC8714201 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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Serotype Replacement after Introduction of 10-Valent and 13-Valent Pneumococcal Conjugate Vaccines in 10 Countries, Europe.

Hanquet Germaine G   Krizova Pavla P   Dalby Tina T   Ladhani Shamez N SN   Nuorti J Pekka JP   Danis Kostas K   Mereckiene Jolita J   Knol Mirjam J MJ   Winje Brita A BA   Ciruela Pilar P   de Miguel Sara S   Portillo Maria Eugenia ME   MacDonald Laura L   Morfeldt Eva E   Kozakova Jana J   Valentiner-Branth Palle P   Fry Norman K NK   Rinta-Kokko Hanna H   Varon Emmanuelle E   Corcoran Mary M   van der Ende Arie A   Vestrheim Didrik F DF   Munoz-Almagro Carmen C   Sanz Juan-Carlos JC   Castilla Jesus J   Smith Andrew A   Henriques-Normark Birgitta B   Colzani Edoardo E   Pastore-Celentano Lucia L   Savulescu Camelia C  

Emerging infectious diseases 20220101 1


We evaluated invasive pneumococcal disease (IPD) during 8 years of infant pneumococcal conjugate vaccine (PCV) programs using 10-valent (PCV10) and 13-valent (PCV13) vaccines in 10 countries in Europe. IPD incidence declined during 2011-2014 but increased during 2015-2018 in all age groups. From the 7-valent PCV period to 2018, IPD incidence declined by 42% in children <5 years of age, 32% in persons 5-64 years of age, and 7% in persons >65 years of age; non-PCV13 serotype incidence increased by  ...[more]

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