Vanadate inhibits Feo-mediated iron transport in Vibrio cholerae.
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ABSTRACT:
SUBMITTER: Shin M
PROVIDER: S-EPMC8715895 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
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Vanadate inhibits Feo-mediated iron transport in Vibrio cholerae.
Shin Minhye M Gomez-Garzon Camilo C Payne Shelley M SM
Metallomics : integrated biometal science 20211101 11
Iron is an essential element for Vibrio cholerae to survive, and Feo, the major bacterial system for ferrous iron transport, is important for growth of this pathogen in low-oxygen environments. To gain insight into its biochemical mechanism, we evaluated the effects of widely used ATPase inhibitors on the ATP hydrolysis activity of the N-terminal domain of V. cholerae FeoB. Our results showed that sodium orthovanadate and sodium azide effectively inhibit the catalytic activity of the N-terminal ...[more]
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