Efficacy of Prucalopride for Chronic Idiopathic Constipation: An Analysis of Participants With Moderate to Very Severe Abdominal Bloating.
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ABSTRACT: Introduction
This post hoc analysis evaluated the effect of prucalopride on abdominal bloating in participants with chronic idiopathic constipation (CIC) who had moderate to very severe bloating at baseline.Methods
Data from 6 phase 3/4 studies of prucalopride in participants with CIC were pooled. Abdominal bloating was assessed weekly using a 5-point scale (0-4).Results
The proportion of bloating responders (≥1-point improvement in abdominal bloating score at week 12) was higher in participants treated with prucalopride (62.1%) vs placebo (49.6%).Discussion
The prucalopride arm had a higher proportion of bloating responders vs placebo in this study population.
SUBMITTER: Staller K
PROVIDER: S-EPMC8715996 | biostudies-literature |
REPOSITORIES: biostudies-literature
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