Ontology highlight
ABSTRACT:
SUBMITTER: Grace CA
PROVIDER: S-EPMC8717319 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Grace Cooper Alastair CA Forrester Sarah S Silva Vladimir Costa VC Carvalho Kátia Silene Sousa KSS Kilford Hannah H Chew Yen Peng YP James Sally S Costa Dorcas L DL Mottram Jeremy C JC Costa Carlos C H N CCHN Jeffares Daniel C DC
Genome biology and evolution 20211201 12
The Leishmania donovani species complex is the causative agent of visceral leishmaniasis, which cause 20-40,000 fatalities a year. Here, we conduct a screen for balancing selection in this species complex. We used 384 publicly available L. donovani and L. infantum genomes, and sequence 93 isolates of L. infantum from Brazil to describe the global diversity of this species complex. We identify five genetically distinct populations that are sufficiently represented by genomic data to search for si ...[more]