Multi-Omics Analysis of Fatty Acid Metabolism in Thyroid Carcinoma.

ABSTRACT:

Objective

Papillary thyroid carcinoma (PTC) accounts for the majority of thyroid cancer and affects a large number of individuals. The pathogenesis of PTC has not been completely elucidated thus far. Metabolic reprogramming is a common feature in tumours. Our previous research revealed the reprogramming of lipid metabolism in PTC. Further studies on lipid metabolism reprogramming may help elucidate the pathogenesis of PTC.

Methods

Clinical samples of PTC and para-tumour tissue were analysed using lipidomic, proteomic, and metabolomic approaches. A multi-omics integrative strategy was adopted to identify the important pathways in PTC. The findings were further confirmed using western blotting, tissue microarray, bioinformatics, and cell migration assays.

Results

Multi-

SUBMITTER: Lu J 

PROVIDER: S-EPMC8717782 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature