Ontology highlight
ABSTRACT:
SUBMITTER: Xu Z
PROVIDER: S-EPMC8718768 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Xu Zongren Z Liao Xingyun X Li Na N Zhou Hongxiu H Li Hong H Zhang Qi Q Hu Ke K Yang Peizeng P Hou Shengping S
Frontiers in cell and developmental biology 20211217
Human retinal pigment epithelium cells are arranged in a monolayer that plays an important supporting role in the retina. Although the heterogeneity of specific retinal cells has been well studied, the diversity of hRPE cells has not been reported. Here, we performed a single-cell RNA sequencing on 9,302 hRPE cells from three donors and profiled a transcriptome atlas. Our results identified two subpopulations that exhibit substantial differences in gene expression patterns and functions. One of ...[more]