Neuroimaging correlates of Stages of Objective Memory Impairment (SOMI) system.

ABSTRACT:

Introduction

To assess the relationship between memory performance defined by the Stages of Objective Memory Impairment (SOMI) system and the Alzheimer's disease (AD) ATN (amyloid beta [A], pathologic tau [T], and neurodegeneration [N]) biomarker system.

Methods

We used data from the Harvard Aging Brain Study cohort to estimate the level of ATN biomarkers: amyloid beta (C-Pittsburgh compound B-positron emission tomography [PET]), tau (F-18-flortaucipir [FTP] PET), and neurodegeneration (magnetic resonance imaging volumetrics). We assessed the cross-sectional relationship of SOMI classification with global amyloid levels, entorhinal and inferior temporal tau deposition, and hippocampal atrophy.

Results

Participants with both memory storage and retrieval deficits (SOMI-

SUBMITTER: Grober E 

PROVIDER: S-EPMC8719429 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature