Plasmodium berghei-Released Factor, PbTIP, Modulates the Host Innate Immune Responses.

ABSTRACT: The Plasmodium parasite has to cross various immunological barriers for successful infection. Parasites have evolved mechanisms to evade host immune responses, which hugely contributes to the successful infection and transmission by parasites. One way in which a parasite evades immune surveillance is by expressing molecular mimics of the host molecules in order to manipulate the host responses. In this study, we report a Plasmodium berghei hypothetical protein, PbTIP (PbANKA_124360.0), which is a Plasmodium homolog of the human T-cell immunomodulatory protein (TIP). The latter possesses immunomodulatory activities and suppressed the host immune responses in a mouse acute graft-versus-host disease (GvHD) model. The Plasmodium berghei protein, Pb<

SUBMITTER: Kalia I 

PROVIDER: S-EPMC8721568 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature