Discovering novel mechanisms of taxane resistance in human breast cancer by whole-exome sequencing.

ABSTRACT: Taxanes are important drugs used in the treatment of breast cancer; however, some cancer types are taxane-resistant. The aim of the present study was to investigate the underlying mechanisms of taxane resistance using whole-exome sequencing (WES). Six patients with breast cancer whose tumors responded well to anthracycline treatment but grew rapidly during neoadjuvant taxane-based chemotherapy, were included in the present study. WES of samples from these patients was carried out to identify somatic mutations of candidate genes thought to affect taxane resistance, and the candidate proteins were structurally modeled. The mRNA and protein expression levels of these candidate genes in other breast cancers treated with taxanes were also examined. Nine variants common to all six patients were

SUBMITTER: Wanifuchi-Endo Y 

PROVIDER: S-EPMC8721851 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature