Ontology highlight
ABSTRACT:
SUBMITTER: Wang S
PROVIDER: S-EPMC8721934 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Wang Sheng S Liu Lizhen L Wang Can C Wang Ziqiang Z Duan Xuhua X Chen Gang G Zhou Hu H Shao Hong H
Biosafety and health 20220103 1
The coronavirus disease 2019 (COVID-19) is still causing a wide range of infections and deaths due to the high variability of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Therefore, it is necessary to establish a reliable and convenient pseudovirus-based neutralization assay to develop drug targeted variants of SARS-CoV-2. Based on the HIV-1 backbone, we generated a high titer luciferase (Luc)-expressing pseudovirus packaging system. Three dominant S mutant substitution pseu ...[more]