Ontology highlight
ABSTRACT:
SUBMITTER: Chen Z
PROVIDER: S-EPMC8722388 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Chen Zhiyuan Z Xie Zhenfei Z Zhang Yi Y
Development (Cambridge, England) 20211221 24
How maternal factors in oocytes initiate zygotic genome activation (ZGA) remains elusive in mammals, partly due to the challenge of de novo identification of key factors using scarce materials. Two-cell (2C)-like cells have been widely used as an in vitro model in order to understand mouse ZGA and totipotency because of their expression of a group of two-cell embryo-specific genes and their simplicity for genetic manipulation. Recent studies indicate that DPPA2 and DPPA4 are required for establi ...[more]