Ontology highlight
ABSTRACT:
SUBMITTER: Bae Y
PROVIDER: S-EPMC8723982 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 20220101 1
The development of selective targeting of drug molecules towards the mitochondria is an important issue related to therapy efficacy. In this study, we report that gallic acid (GA)-mitochondria targeting sequence (MTS)-H<sub>3</sub>R<sub>9</sub> exhibits a dual role as a mitochondria-targeting vehicle with antioxidant activity for disease therapy. In viability assays, GA-MTS-H<sub>3</sub>R<sub>9</sub> showed a better rescue action compared to that of MTS-H<sub>3</sub>R<sub>9</sub>. GA-MTS-H<sub>3 ...[more]