Ontology highlight
ABSTRACT:
SUBMITTER: Fujii T
PROVIDER: S-EPMC8724116 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Fujii Tomoko T Salanti Georgia G Belletti Alessandro A Bellomo Rinaldo R Carr Anitra A Furukawa Toshi A TA Luethi Nora N Luo Yan Y Putzu Alessandro A Sartini Chiara C Tsujimoto Yasushi Y Udy Andrew A AA Yanase Fumitaka F Young Paul J PJ
Intensive care medicine 20211109 1
We aimed to compare the effects of vitamin C, glucocorticoids, vitamin B1, combinations of these drugs, and placebo or usual care on longer-term mortality in adults with sepsis or septic shock. MEDLINE, Embase, CENTRAL, ClinicalTrials.gov and WHO-ICTRP were searched. The final search was carried out on September 3rd, 2021. Multiple reviewers independently selected randomized controlled trials (RCTs) comparing very-high-dose vitamin C (≥ 12 g/day), high-dose vitamin C (< 12, ≥ 6 g/day), vitamin C ...[more]