Ontology highlight
ABSTRACT:
SUBMITTER: Zeybel M
PROVIDER: S-EPMC8724764 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Zeybel Mujdat M Altay Ozlem O Arif Muhammad M Li Xiangyu X Yang Hong H Fredolini Claudia C Akyildiz Murat M Saglam Burcin B Gonenli Mehmet Gokhan MG Ural Dilek D Kim Woonghee W Schwenk Jochen M JM Zhang Cheng C Shoaie Saeed S Nielsen Jens J Uhlén Mathias M Borén Jan J Mardinoglu Adil A
Molecular systems biology 20211001 10
Nonalcoholic fatty liver disease (NAFLD) refers to excess fat accumulation in the liver. In animal experiments and human kinetic study, we found that administration of combined metabolic activators (CMAs) promotes the oxidation of fat, attenuates the resulting oxidative stress, activates mitochondria, and eventually removes excess fat from the liver. Here, we tested the safety and efficacy of CMA in NAFLD patients in a placebo-controlled 10-week study. We found that CMA significantly decreased h ...[more]