Drosophila Med6 is required for elevated expression of a large but distinct set of developmentally regulated genes.
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ABSTRACT:
SUBMITTER: Gim BS
PROVIDER: S-EPMC87248 | biostudies-literature | 2001 Aug
REPOSITORIES: biostudies-literature
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Drosophila Med6 is required for elevated expression of a large but distinct set of developmentally regulated genes.
Gim B S BS Park J M JM Yoon J H JH Kang C C Kim Y J YJ
Molecular and cellular biology 20010801 15
Mediator is the evolutionarily conserved coactivator required for the integration and recruitment of diverse regulatory signals to basal transcription machinery. To elucidate the functions of metazoan Mediator, we isolated Drosophila melanogaster Med6 mutants. dMed6 is essential for viability and/or proliferation of most cells. dMed6 mutants failed to pupate and died in the third larval instar with severe proliferation defects in imaginal discs and other larval mitotic cells. cDNA microarray, qu ...[more]
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