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Caseous necrosis of the mitral annulus: a new feature of drug-induced valvular heart disease? Case series.

ABSTRACT:

Background

Drug-induced valvular heart disease (DI-VHD) is a well-defined condition associated with specific pathology features. However, clinical presentations may broadly vary and thereby make DI-VHD diagnosis more challenging.

Case summary

We report two patients with a history of benfluorex administration, who developed extensive mitral calcific lesions which evolved towards caseous necrosis.

Discussion

Prospective follow-up over several years of these two patients who initially had typical DI-VHD findings provided monitoring evidence of extensive calcifications and subsequent caseous necrosis. These reports suggest a link between calcific heart injury and benfluorex exposure. The diagnosis of DI-VHD may be overlooked at this late stage.

SUBMITTER: Leblon T

PROVIDER: S-EPMC8727063 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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Caseous necrosis of the mitral annulus: a new feature of drug-induced valvular heart disease? Case series.

Leblon Tiphaine T Riolet Clemence C Ennezat PierreVladimir P Marechaux Sylvestre S

European heart journal. Case reports 20211216 1

<h4>Background</h4>Drug-induced valvular heart disease (DI-VHD) is a well-defined condition associated with specific pathology features. However, clinical presentations may broadly vary and thereby make DI-VHD diagnosis more challenging.<h4>Case summary</h4>We report two patients with a history of benfluorex administration, who developed extensive mitral calcific lesions which evolved towards caseous necrosis.<h4>Discussion</h4>Prospective follow-up over several years of these two patients who i ...[more]

PMID: 34993414

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