Dataset Information

Relationship Between Changes in the Choroidal Structure and Blood Flow of the Macula After Trabeculectomy.

ABSTRACT:

Purpose

To elucidate the relationship between changes in the choroidal structure and blood flow of the macula after trabeculectomy.

Methods

A prospective study of 30 eyes of 30 patients with glaucoma who underwent trabeculectomy. Enhanced depth imaging optical coherence tomography with choroidal image binarization and laser speckle flowgraphy of the macula were performed at baseline and 1, 3, and 6 months postoperatively. Mixed-effects models with adjustment for confounders were used to analyze longitudinal changes in the mean choroidal thickness (mCT), mean choroidal vascular thickness (mCVT), mean choroidal interstitial thickness (mCIT), and mean blur rate (MBR).

Results

The decrease in the intraocular pressure (IOP; 45%-51%) and axial length (0.5%-0.8%) and the increase in ocular perfusion pressure (OPP; 34%-38%), mCT (16%-19%), mCVT (16%-20%), mCIT (17%-20%), and MBR (22%-25%) were significant at each postoperative time point (all P < 0.001). In the multivariate analysis, the mCVT changes were positively correlated with the OPP and MBR changes (P = 0.04 and P < 0.001, respectively), whereas the mCIT changes were negatively correlated with IOP changes (P = 0.005). The MBR changes correlated significantly with changes in mCVT but not mCIT (P < 0.001 and P = 0.39, respectively).

Conclusions

Thickness changes in the intraluminal and extraluminal parts of the choroid were closely associated with changes in blood flow and IOP, respectively, although both parts thickened comparably after IOP reduction by trabeculectomy.

Translational relevance

The choroid reacts to IOP reduction differently between the intraluminal and extraluminal areas, blood flow dependence in the vascular area, and IOP dependence in the stromal area.

SUBMITTER: Takamatsu Y

PROVIDER: S-EPMC8727312 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Publications

Relationship Between Changes in the Choroidal Structure and Blood Flow of the Macula After Trabeculectomy.

Takamatsu Yuki Y Higashide Tomomi T Takeshima Satoshi S Sasaki Makoto M Manbo Yoshimi Y Udagawa Sachiko S Ohkubo Shinji S Sonoda Shozo S Sakamoto Taiji T Sugiyama Kazuhisa K

Translational vision science & technology 20211201 14

<h4>Purpose</h4>To elucidate the relationship between changes in the choroidal structure and blood flow of the macula after trabeculectomy.<h4>Methods</h4>A prospective study of 30 eyes of 30 patients with glaucoma who underwent trabeculectomy. Enhanced depth imaging optical coherence tomography with choroidal image binarization and laser speckle flowgraphy of the macula were performed at baseline and 1, 3, and 6 months postoperatively. Mixed-effects models with adjustment for confounders were u ...[more]

PMID: 34964835

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Project description:BackgroundThe eyeball axial length (AL) is an important biological indicator of myopia, which has been widely studied. However, little research has been conducted on the relationship between eye shape and fundus structural changes in myopia. This study aimed to analyze the relationship between the shape of the posterior pole of the eye, and choroidal characteristics by comparing with the relationship between AL and choroidal characteristics. And to investigate the clinical significance of the shape of the posterior pole in the pathophysiological changes related to myopia.MethodsIn this study, the data of 147 eyes (22 emmetropic and 125 myopic) of participants aged 20-30 years, examined in 2021, were collected. Optical coherence tomography (OCT) was used to analyze the posterior-pole images, choroidal thickness (ChT), choroidal vascular volume (CVV), and three-dimensional choroidal vascular index (3DCVI). The least squares method was used to fit the ellipse that was most consistent with the actual shape of the posterior pole. Multiple stepwise regression analysis was used to investigate the relationships between the fitting posterior-pole vertex curvature (fPVC), and ChT, CVV, and 3DCVI.ResultsThe mean AL of the participants was 25.15±1.35 mm (22.30-27.92 mm), the mean spherical equivalent was -3.59±2.62 D (+0.5 to -11.75 D), and the mean fPVC was 0.158±0.036 mm-1. The fPVC was positively correlated with the AL (r=0.639, P<0.001)and negatively correlated with the spherical equivalent (r=-0.666, P<0.001). The AL and fPVC were independently negatively correlated with the ChT and CVV in the macular region (0-6 mm). In the peripheral area (6-9 mm), the fPVC (ChT: β=-0.529, P<0.001; CVV: β=-0.441, P<0.001) was more closely associated with the ChT and CVV than the AL (ChT: β=-0.140, P=0.127; CVV: β=-0.127, P=0.190). The 3DCVI may be nonlinearly correlated with the AL and fPVC, and the relationship curve between the fPVC and 3DCVI was clearer than that between the AL and 3DCVI.ConclusionsIn addition to the AL, the shape of the posterior pole is related to the ChT and choroidal vascular changes, and more closely related to the peripheral choroid than AL. Our findings provide another perspective for the prevention and monitoring of myopic-related pathological changes in clinical practice.

Dataset Information

Relationship Between Changes in the Choroidal Structure and Blood Flow of the Macula After Trabeculectomy.

Purpose

Methods

Results

Conclusions

Translational relevance

Publications

Relationship Between Changes in the Choroidal Structure and Blood Flow of the Macula After Trabeculectomy.

Similar Datasets

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