Blood DNA methylation profiles improve breast cancer prediction.
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ABSTRACT:
SUBMITTER: Kresovich JK
PROVIDER: S-EPMC8732352 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Publications
Blood DNA methylation profiles improve breast cancer prediction.
Kresovich Jacob K JK Xu Zongli Z O'Brien Katie M KM Shi Min M Weinberg Clarice R CR Sandler Dale P DP Taylor Jack A JA
Molecular oncology 20211109 1
Although blood DNA methylation (DNAm) profiles are reported to be associated with breast cancer incidence, they have not been widely used in breast cancer risk assessment. Among a breast cancer case-cohort of 2774 women (1551 cases) in the Sister Study, we used candidate CpGs and DNAm estimators of physiologic characteristics to derive a methylation-based breast cancer risk score, mBCRS. Overall, 19 CpGs and five DNAm estimators were selected using elastic net regularization to comprise mBCRS. I ...[more]
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