Phenotypic characteristics of incident and chronic MRSA isolates in cystic fibrosis.

ABSTRACT:

Background

Chronic methicillin resistant Staphylococcus aureus (MRSA) in CF is associated with worse outcomes compared to early or intermittent infection. This observation could be related to adaptive bacterial changes such as biofilm formation or anaerobic growth.

Methods

MRSA isolates stored from incident and during chronic (>2 years) infection were included at two study sites. MRSA isolates were characterised by spa-typing, antimicrobial susceptibility testing, biofilm formation and haemolysis under aerobic and anaerobic culture conditions.

Results

Paired MRSA isolates from 49 patients were included. Mean age at incident infection was 9.7±1.2 years with mild to moderate lung disease (FEV₁ 74±4% predicted). Twenty-five subjects showed progression of disea

SUBMITTER: Gilpin D 

PROVIDER: S-EPMC8734588 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature