Dataset Information

Bringing Home Baby Euclid: Testing Infants' Basic Shape Discrimination Online.

ABSTRACT: Online developmental psychology studies are still in their infancy, but their role is newly urgent in the light of the COVID-19 pandemic and the suspension of in-person research. Are online studies with infants a suitable stand-in for laboratory-based studies? Across two unmonitored online experiments using a change-detection looking-time paradigm with 96 7-month-old infants, we found that infants did not exhibit measurable sensitivities to the basic shape information that distinguishes between 2D geometric forms, as had been observed in previous laboratory experiments. Moreover, while infants were distracted in our online experiments, such distraction was nevertheless not a reliable predictor of their ability to discriminate shape information. Our findings suggest that the change-detection paradigm may not elicit infants' shape discrimination abilities when stimuli are presented on small, personal computer screens because infants may not perceive two discrete events with only one event displaying uniquely changing information that draws their attention. Some developmental paradigms used with infants, even those that seem well-suited to the constraints and goals of online data collection, may thus not yield results consistent with the laboratory results that rely on highly controlled settings and specialized equipment, such as large screens. As developmental researchers continue to adapt laboratory-based methods to online contexts, testing those methods online is a necessary first step in creating robust tools and expanding the space of inquiry for developmental science conducted online.

SUBMITTER: Bochynska A

PROVIDER: S-EPMC8734637 | biostudies-literature |

REPOSITORIES: biostudies-literature

ACCESS DATA

Similar Datasets

Project description:IntroductionDisparities in the care and outcomes of peripheral artery disease (PAD) have been well-established. In part this is due to disparities in enrollment of PAD trial cohorts. However, less attention has been paid to non-random protocol non-adherence after enrollment, which may lead to inaccurate estimates of treatment effects and reduce generalizability of study results. We aimed to ascertain characteristics associated with premature study drug discontinuation in a PAD cohort.MethodsUsing data from EUCLID (Examining Use of Ticagrelor in Peripheral Artery Disease), factors associated with study drug discontinuation were assessed using univariable and multivariable Cox proportional hazards models with time to study drug discontinuation as the outcome of interest. Relationships between study drug discontinuation and major adverse cardiovascular events (MACE; cardiovascular death, myocardial infarction, ischemic stroke), major adverse limb events (MALE; acute limb ischemia, major amputation, and lower extremity revascularization), and all-cause hospitalization were assessed.ResultsOf 13,842 eligible EUCLID participants, 3,886 (28.1%) prematurely and permanently discontinued study drug over a maximum follow-up of 42 months (annualized rate of 13.2 discontinuations per 100 patient-years). In a multivariable model, premature study drug discontinuation was associated with older age (aHR 1.16, 95%CI 1.14-1.19), eligibility based on prior lower extremity revascularization rather than ABI/TBI criteria (aHR 1.14, 95%CI 1.06-1.23), CLI status (aHR 1.23, 95%CI 1.06-1.42), COPD (aHR 1.36, 95%CI 1.24-1.49), and geographic region. In a multivariable analysis, study drug discontinuation was significantly associated with MACE (aHR 3.27, 95%CI 2.90-3.67, p < 0.001), MALE (aHR 1.84, 95%CI 1.63-2.07, p < 0.001), and all-cause hospitalization (aHR 2.37, 95%CI 2.21-2.54) following study drug discontinuation.ConclusionsThis analysis of EUCLID demonstrates that premature, permanent discontinuation of study drug is relatively common in more than a quarter of PAD patients, is unevenly distributed based on geography and other baseline characteristics, and is associated with worse outcomes in a clinical trial context. Study teams leading future PAD trials may want to address the possibility of study drug discontinuation prospectively, as a proactive approach may help investigators to maintain study cohort diversity and representativeness without sacrificing power and precision.

Dataset Information

Bringing Home Baby Euclid: Testing Infants' Basic Shape Discrimination Online.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets