Ontology highlight
ABSTRACT:
SUBMITTER: Yang Y
PROVIDER: S-EPMC8737402 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Yang Yinxian Y Zuo Shiyi S Li Linxiao L Kuang Xiao X Li Jinbo J Sun Bingjun B Wang Shujun S He Zhonggui Z Sun Jin J
Asian journal of pharmaceutical sciences 20210606 6
Ferroptosis is a new mode of cell death, which can be induced by Fenton reaction-mediated lipid peroxidation. However, the insufficient H<sub>2</sub>O<sub>2</sub> and high GSH in tumor cells restrict the efficiency of Fenton reaction-dependent ferroptosis. Herein, a self-supplying lipid peroxide nanoreactor was developed to co-delivery of doxorubicin (DOX), iron and unsaturated lipid for efficient ferroptosis. By leveraging the coordination effect between DOX and Fe<sup>3+</sup>, trisulfide bond ...[more]