Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC8740755 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Zhang Yong Y Fu Jiaqi J Liu Shuxin S Wang Lidong L Qiu Jiazhang J van Schaik Erin J EJ Samuel James E JE Song Lei L Luo Zhao-Qing ZQ
Proceedings of the National Academy of Sciences of the United States of America 20220101 1
<i>Coxiella burnetii</i> is a bacterial pathogen that replicates within host cells by establishing a membrane-bound niche called the <i>Coxiella</i>-containing vacuole. Biogenesis of this compartment requires effectors of its Dot/Icm type IV secretion system. A large cohort of such effectors has been identified, but the function of most of them remain elusive. Here, by a cell-based functional screening, we identified the effector Cbu0513 (designated as CinF) as an inhibitor of NF-κB signaling. C ...[more]