Ontology highlight
ABSTRACT:
SUBMITTER: Walker MR
PROVIDER: S-EPMC8741191 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Walker Melanie R MR Goel Hira Lal HL Mukhopadhyay Dimpi D Chhoy Peter P Karner Emmet R ER Clark Jennifer L JL Liu Haibo H Li Rui R Zhu Julie Lihua JL Chen Shuhui S Mahal Lara K LK Bensing Barbara A BA Mercurio Arthur M AM
Science advances 20220107 1
We pursued the hypothesis that specific glycans can be used to distinguish breast cancer stem cells (CSCs) and influence their function. Comparison of CSCs and non-CSCs from multiple breast cancer models revealed that CSCs are distinguished by expression of α2,3 sialylated core2 O-linked glycans. We identified a lectin, SLBR-N, which binds to O-linked α2,3 sialic acids, that was able to enrich for CSCs in vitro and in vivo. This O-glycan is expressed on CD44 and promotes its interaction with hya ...[more]