Ontology highlight
ABSTRACT:
SUBMITTER: Chen Z
PROVIDER: S-EPMC8741493 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Chen Zhe Z Lin Ming-Tong MT Zhan Chen C Zhong Nan-Shan NS Mu Di D Mu Di D Lai Ke-Fang KF Liu Mingzhe J MJ
iScience 20211216 1
Chronic cough is a common refractory symptom of various respiratory diseases. However, the neural mechanisms that modulate the cough sensitivity and mediate chronic cough remain elusive. Here, we report that GABAergic neurons in the lateral/ventrolateral periaqueductal gray (l/vlPAG) suppress cough processing via a descending pathway. We found that l/vlPAG neurons are activated by coughing-like behaviors and that tussive agent-evoked coughing-like behaviors are impaired after activation of l/vlP ...[more]