Novel Insights Into the Multifaceted Functions of RNA n⁶-Methyladenosine Modification in Degenerative Musculoskeletal Diseases.

ABSTRACT: N⁶-methyladenosine (m⁶A) is an important modification of eukaryotic mRNA. Since the first discovery of the corresponding demethylase and the subsequent identification of m⁶A as a dynamic modification, the function and mechanism of m⁶A in mammalian gene regulation have been extensively investigated. "Writer", "eraser" and "reader" proteins are key proteins involved in the dynamic regulation of m⁶A modifications, through the anchoring, removal, and interpretation of m⁶A modifications, respectively. Remarkably, such dynamic modifications can regulate the progression of many diseases by affecting RNA splicing, translation, export and degradation. Emerging evidence has identified the relationship between m⁶A modificati

SUBMITTER: Li H 

PROVIDER: S-EPMC8743268 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature