Risk of Diabetes in Patients with Long-Standing Graves' Disease: A Longitudinal Study.

ABSTRACT:

Background

The detrimental effects of excessive thyroid hormone on glucose metabolism have been widely investigated. However, the risk of diabetes in patients with long-standing hyperthyroidism, especially according to treatment modality, remains uncertain, with few longitudinal studies.

Methods

The risk of diabetes in patients with Graves' disease treated with antithyroid drugs (ATDs) for longer than the conventional duration (≥2 years) was compared with that in age-and sex-matched controls. The risk was further compared according to subsequent treatment modalities after a 24-month course of ATD: continuation of ATD (ATD group) vs. radioactive iodine ablation (RIA) group.

Results

A total of 4,593 patients were included. Diabetes was diagnosed in 751 (16.3%) patients

SUBMITTER: Song E 

PROVIDER: S-EPMC8743588 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature