Ontology highlight
ABSTRACT:
SUBMITTER: Putra P
PROVIDER: S-EPMC8746141 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Putra Prama P Thompson Travis B TB Chaggar Pavanjit P Goriely Alain A
Network neuroscience (Cambridge, Mass.) 20211130 4
A hallmark of Alzheimer's disease is the aggregation of insoluble amyloid-beta plaques and tau protein neurofibrillary tangles. A key histopathological observation is that tau protein aggregates follow a structured progression pattern through the brain. Mathematical network models of prion-like propagation have the ability to capture such patterns, but a number of factors impact the observed staging result, thus introducing questions regarding model selection. Here, we introduce a novel approach ...[more]