Association of Escherichia coli containing polyketide synthase in the gut microbiota with colorectal neoplasia in Japan.

ABSTRACT: Escherichia coli containing polyketide synthase in the gut microbiota (pks⁺ E coli) produce a polyketide-peptide genotoxin, colibactin, and are suspected to play a role in the development of colorectal neoplasia. To clarify the role of pks⁺ E coli in the early stage of tumorigenesis, we investigated whether the pks status of E coli was associated with the prevalence of colorectal neoplasia. This cross-sectional analysis of data from a prospective cohort in Izu Oshima, Japan included asymptomatic residents aged 40-79 years who underwent screening colonoscopy and provided a stool sample. We identified 543 participants with colorectal neoplasia (22 colorectal cancer and 521 adenoma) as cases and 425 participants with normal colon as controls. The pks status of E coli was

SUBMITTER: Iwasaki M 

PROVIDER: S-EPMC8748232 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature