Ontology highlight
ABSTRACT:
SUBMITTER: Deganutti G
PROVIDER: S-EPMC8748714 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Deganutti Giuseppe G Liang Yi-Lynn YL Zhang Xin X Khoshouei Maryam M Clydesdale Lachlan L Belousoff Matthew J MJ Venugopal Hari H Truong Tin T TT Glukhova Alisa A Keller Andrew N AN Gregory Karen J KJ Leach Katie K Christopoulos Arthur A Danev Radostin R Reynolds Christopher A CA Zhao Peishen P Sexton Patrick M PM Wootten Denise D
Nature communications 20220110 1
The glucagon-like peptide-1 receptor (GLP-1R) has broad physiological roles and is a validated target for treatment of metabolic disorders. Despite recent advances in GLP-1R structure elucidation, detailed mechanistic understanding of how different peptides generate profound differences in G protein-mediated signalling is still lacking. Here we combine cryo-electron microscopy, molecular dynamics simulations, receptor mutagenesis and pharmacological assays, to interrogate the mechanism and conse ...[more]