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Spatiotemporal slip distributions associated with the 2018-2019 Bungo Channel long-term slow slip event inverted from GNSS data.

ABSTRACT: Long-term slow slip events (L-SSEs) have repeatedly occurred beneath the Bungo Channel in southwestern Japan with durations of several months to a couple of years, with a recurrence interval of approximately 6 years. We estimated the spatiotemporal slip distributions of the 2018-2019 Bungo Channel L-SSE by inverting processed GNSS time series data. This event was divided into two subevents, with the first on the southwest side of the Bungo Channel from 2018.3 to 2018.7 and the second beneath the Bungo Channel from 2018.8 to 2019.4. Tectonic tremors became active on the downdip side of the L-SSE occurrence region when large slow slips took place beneath the Bungo Channel. Compared with the previous Bungo Channel L-SSEs, this spatiotemporal slip pattern and amount were similar to those of the 2002-2004 L-SSE. However, the slip expanded in the northeast and southwest directions in the latter half of the second subevent. The maximum amount of slip, the maximum slip velocity, the total released seismic moment, and the moment magnitude of the 2018-2019 L-SSE were estimated to be 28 cm, 54 cm/year, [Formula: see text] Nm, and 7.0, respectively, all of which were the largest among the 1996-1998, 2002-2004, 2009-2011, and 2018-2019 L-SSEs.

SUBMITTER: Seshimo Y

PROVIDER: S-EPMC8748931 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:CLC-0, a prototype Cl- channel in the CLC family, employs two gating mechanisms that control its ion-permeation pore: fast gating and slow gating. The negatively-charged sidechain of a pore glutamate residue, E166, is known to be the fast gate, and the swinging of this sidechain opens or closes the pore of CLC-0 on the millisecond time scale. The other gating mechanism, slow gating, operates with much slower kinetics in the range of seconds to tens or even hundreds of seconds, and it is thought to involve still-unknown conformational rearrangements. Here, we find that low intracellular pH (pHi) facilitates the closure of the CLC-0's slow gate, thus generating current inhibition. The rate of low pHi-induced current inhibition increases with intracellular H+ concentration ([H+]i)-the time constants of current inhibition by low pHi = 4.5, 5.5 and 6 are roughly 0.1, 1 and 10 sec, respectively, at room temperature. In comparison, the time constant of the slow gate closure at pHi = 7.4 at room temperature is hundreds of seconds. The inhibition by low pHi is significantly less prominent in mutants favoring the slow-gate open state (such as C212S and Y512A), further supporting the fact that intracellular H+ enhances the slow-gate closure in CLC-0. A fast inhibition by low pHi causes an apparent inverted voltage-dependent activation in the wild-type CLC-0, a behavior similar to those in some channel mutants such as V490W in which only membrane hyperpolarization can open the channel. Interestingly, when V490W mutation is constructed in the background of C212S or Y512A mutation, the inverted voltage-dependent activation disappears. We propose that the slow kinetics of CLC-0's slow-gate closure may be due to low [H+]i rather than due to the proposed large conformational change of the channel protein. Our results also suggest that the inverted voltage-dependent opening observed in some mutant channels may result from fast closure of the slow gate by the mutations.

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Spatiotemporal slip distributions associated with the 2018-2019 Bungo Channel long-term slow slip event inverted from GNSS data.

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