Allergy-induced systemic inflammation impairs tendon quality.

ABSTRACT:

Background

Treatment of degenerating tendons still presents a major challenge, since the aetiology of tendinopathies remains poorly understood. Besides mechanical overuse, further known predisposing factors include rheumatoid arthritis, diabetes, obesity or smoking all of which combine with a systemic inflammation.

Methods

To determine whether the systemic inflammation accompanying these conditions contributes to the onset of tendinopathy, we studied the effect of a systemic inflammation induced by an allergic episode on tendon properties. To this end, we induced an allergic response in mice by exposing them to a timothy grass pollen allergen and subsequently analysed both their flexor and Achilles tendons. Additionally, we analysed data from a health survey comprising data

SUBMITTER: Lehner C 

PROVIDER: S-EPMC8749446 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature